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Mechanism of Action Nitric Oxide Synthase Pathway : L-citrulline works by converting to arginine through the urea cycle via argininosuccinate synthase and argininosuccinate lyase enzymes, then interacting with nitric oxide synthase (NOS) enzymes to generate nitric oxide and support the relaxation of blood vessel smooth muscle

Trends Neurosci 2008

& Tenenbaum, A

Dietary selenium affects host selenoproteome expression by influencing the gut microbiota

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However, the opposite has also been shown to be true: Theres evidencealthough primarily in animal studiesthat increasing NAD levels may slow aging